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The SARS-CoV-2 Omicron Variant

06-Jan-2022

On 26 November 2021, the WHO designated the SARS-CoV-2 variant B.1.1.529 to be the fifth Variant of Concern (VOC) and assigned it the name “Omicron”. Of the more than 50 mutations in its genome, at least 32 are in the spike protein with fifteen point mutations in the RBD (Figure 1), including several found in other VOCs linked to increased transmissibility and immune evasion. Like other VOCs, mutations are also found in Omicron’s nucleocapsid protein (Figure 2). Omicron is widely distributed and is outcompeting Delta. Though it appears to cause more mild disease, it nevertheless has driven increased hospitalizations.

The SARS-CoV-2 Omicron Variant Spike Mutation Sites

Figure 1. Spike mutation sites found in Omicron are A67V, Δ69-70, T95I, G142D/Δ143-145, Δ211/L212I, ins214EPE, G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493K, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, N764K, D796Y, N856K, Q954H, N969K, L981F.

 

SARS-CoV-2 Omicron Variant Nucleocapsid Mutation Sites

SARS-CoV-2 Delta Variant Nucleocapsid Mutation Sites

Figure 2. Nucleocapsid protein mutation sites found in Omicron are P13L, Δ31-33, R203M, G204R, and in Delta are D63G, R203M, G215C, D377Y.

 

GeneTex has a wide range of recombinant antibody and protein reagents for Omicron research. Notably, nucleocapsid antibodies whose immunogens do not contain any Omicron mutation sites are shown in Figure 2.

 

Highlighted Products
 
Spike RBD Protein, B.1.1.529 / Omicron variant, His tag

Spike RBD Protein, B.1.1.529 / Omicron variant, His tag
(GTX136716-pro)

Nucleocapsid protein, B.1.1.529 / Omicron variant, His tag

Nucleocapsid protein, B.1.1.529 / Omicron variant, His tag
(GTX03400-pro)

Spike RBD antibody [HL257]

Spike RBD antibody [HL257]
(GTX635692)

Spike RBD antibody [HL1014]

Spike RBD antibody [HL1014]
(GTX635807)

Lateral Flow Assay (Recommended Nucleocapsid Antibody Pairs)
Recombinant Abs Citation Support

 

Antibody Pair   Product Name Clonality EC50 Cat. No.
Pair I   Nucleocapsid antibody [HL5511] Rb recAb 14 pM GTX635689
Nucleocapsid antibody [HL448] Rb recAb 11 pM GTX635686
Pair II Nucleocapsid antibody [HL5410] Rb recAb 9 pM GTX635685
Nucleocapsid antibody [HL455] Rb recAb 6 pM GTX635688

 

 

Omicron Spike RBD and Nucleocapsid Recombinant Proteins
 
Product Name Expression System Cat. No.
Spike RBD Protein, B.1.1.529 / Omicron variant, His tag HEK293 GTX136716-pro
Nucleocapsid protein, B.1.1.529 / Omicron variant, His tag E. coli GTX03400-pro

 

 

Recombinant Antibodies that detect Omicron
 
Product Name Applications Cat. No.  
Spike RBD antibody [HL257] WB, ICC/IF, IHC-P, ELISA, IHC-P (cell pellet) GTX635692
Spike RBD antibody [HL1014] ICC/IF, ELISA, Sandwich ELISA GTX635807  
Spike RBD antibody [HL1002] ELISA, Lateral Flow, Neutralizing/Inhibition, Sandwich ELISA GTX635791
Spike RBD antibody [HL1003] ICC/IF, ELISA, Neutralizing/Inhibition, Sandwich ELISA GTX635792